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Are you currently on one or more pharmaceutical drugs? Perhaps you are not aware, but every pharmaceutical drug depletes the body of various nutrients, depriving your cells of the essential raw materials which drive normal, natural cell function. The data on our industrialized food supply already suggestes that each of us is not getting enough nutrition from diet alone. If you’re taking one or more pharmaceutical drugs, your situtation is likely to be even worse.

In the Drug-Induced Nutrient Depletion Handbook the following information is listed.

“HMG CoA Reductase Inhibitors delete the body of Coenzyme Q10, an important nutrient, and that result of this depletion could lead to mitochondrial dysfunction, decreased body function, and decreased cardiac output.”

How could that be affecting your life if you are currently on one of those drugs? Perhaps you should consider a high-quality supplement that contains Qoenzyme Q10 (CoQ10) so make up for your depletion.

If you found our your were iron deficient (anemic), you’d probably take an iron supplement, right?

Other items listed in the Drug-Induced Nutrient Depletion Handbook.

“Many anticonvulsants cause a depletion of Vitamin D, folic acid, and calcium. Depleting these nutrients has the potential to cause problems such as osteoporosis, muscle weakness, blood pressure irregularities, and heart disease.”

In this case, perhaps you should consider a high-quality multivitamin supplement to simply replace the nutrients your body needs.

“Almost every antibiotic causes a disruption of normal bowel flora and a reduction in the production of important vitamins, leading to diarrhea and other gastrointestinal side effects.”

I have a personal experience where my life was saved through antibiotics, but I certainly experienced these side effects. Fortunately there are quality bowel flora supplements which help provide the body with normal levels of intestinal bacteria. This is critical in the metabolization of many vitamins, such as the Vitamin B family.

Here’s what the Drug-Induced Nutrient Depletion Handbook has to say about Estrogen Replacement Therapy.

“Taking Estrogen Replacement Therapy can cause a depletion of important B vitamins, leadingto anxiety, depression, cardiovascular disease, and depression.”

Again perhaps you should choose a high-quality multivitamin supplement and also provide the nutrients that support normal endocrine function.

The Drug-Induced Nutrient Depletion Handbook provides a drug index, which alphabetically lists drugs by both brand and generic name, with cross-references and the scientific basis, studies and abstracts for the research which determined which nutrients are depleted by the particular drug. It also lists nutrient information with concise descriptions of the effects of depletion. What medications are you taking that are depriving your body of essential nutrients?

Have you ever taken the drug Vioxx or celebrex? In September 2004 the drug manufacturer Merck decided to recall the product after long term data suggested a serious potential side effect.

This drug and others like it such as as ‘Celebrex’, ‘Bextra’ and ‘Arcoxia’ are part of a family of drugs known as “COX2 drugs” or “COX2 inhibitors”

They have been developed with, ironically, patient safety in mind.They are typically used in treatment of arthritis, though high dose vioxx was promoted for short term relief of acute muscular/skeletal pains.They were anti-inflammatory drugs.

The serious side effects were in connection with the heart suggesting risk of heart disease or heart attack.In medical circles it was referred to as “..adverse cardiovascular effects.”

There are other drugs used to treat inflammation that have been around for many years.YOu may have heard of products such as Advil or Nurofen which contain the ingredient Ibuprofen.Other older anti-inflammatory drugs include such brands as Voltarol or Naprosyn.

What’s the difference between these older drugs and the recent treatments know as “COX2 drugs”?

The newer drugs such as Arcoxia,Celebrex and Vioxx were designed to be much more specific in their mode action than old drugs like Ibuprofen.The idea was to limit the associated problems in long term treatment.

When we get older we all seem to get more sensitive to side effects of drugs.Often this is complicated even more by the fact that we may suffer from more than one problem or disease at the same time.

At this point we take more medication in the last five to ten years of our lives than in all the other years put together! Is it any wonder we might feel under the weather, a little off colour even?

You could have asthma and high blood pressure. Anxiety and lack of sleep every night. Panic attacks and depression.

If you take an anti-inflammatory drug for a given length of time, your doctor/physician will no doubt tell you about one major problem.

Ulceration of the stomach or intestines…..

It was hoped that the newer COX2 drugs would not cause this problem at all.Therefore it would avoid the risk of someone suffering internal bleeding which could become fatal.

The older you become the greater the risk of this occuring. It could be a slow blood loss or a sudden episode of an ulcer bleeding more profusely.

So when people got the signs of ulcers, they got treatment for an ulcer. Some would stop taking medication and others would take a maintenance dose to prevent ulcers coming back while continuing to take the old ibuprofen drugs for their arthritis.

It was hoped drugs like vioxx would stop this, but ulceration still remains a possibility. Doctors routinely consider offering anti ulcer drugs to reduce the probability of this happening.

So what is the all the recent fuss about ? Where did it all suddenly seem to unravel after all that hope and expectation ? A new long term study seemed to indicate some degree of risk to the heart some 18 months or so after starting treatment.

So if you took vioxx for a week or a couple of months, this potential problem did not appear.It has only been spotted after taking the medication for a longer period such as 18 months.

What can you do? Are there ways to reduce risks? This is something you need advice on as only your doctor will have your medical history.There is much to consider and such a problem can in some circumstances be minimised.

Of course if you smoke you increase the risk of stomach or intestinal ulceration if you also take anti-inflammatory drugs such as Ibuprofen.Why not quit instead?

If you take other medication for depression or anxiety then these drugs can increase the risk of bleeding with any anti-inflammatory drug being taken at the same time.

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Another Vioxx-like occurrence may be on the rise, as warnings about Pfizer’s arthritis pain drug, Bextra, continue to mount.

According to a study of more than 1,500 patients who had previously undergone cardiac surgery, those who were treated for pain with Bextra were more likely to have heart and blood clotting problems than those who received no drug at all.

Associated problems included:

* Stroke

* Heart attack

* Blood clots in the lung

* Deep vein blood clots in the leg

Regardless of the fact that taking Bextra presents such serious health risks, the Food and Drug Administration (FDA) still believes the benefits of the drug outweigh the risks when used by the right patients. In light of these health concerns, however, the FDA approved a new label for the drug, which warns that those who recently had heart surgery (or who are allergic to sulfa products) should not take the drug. The revised label also strengthens the warning of the likelihood of severe skin reactions — two of which may result in death.

Bextra is a cox-2 inhibitor, which is a class of painkillers that are popularly used due to their efficiency in treating arthritis pain and other ailments. Vioxx is also a cox-2 inhibitor and was pulled from the market due to the cardiovascular risks linked to taking the drug.

Considering the health risks involved with cox-2 inhibitors, the FDA will be holding a public advisory meeting to discuss the safety concerns of these and other related drugs.

USA Today December 9, 2004

Dr. Mercola’s Comment:

I have previously posted an article warning that Bextra’s risks are even higher than Vioxx’s. And, as this article stated, the FDA is now modifying Bextra’s label to state that taking the drug after having cardiac surgery could increase one’s likelihood of heart and blood clotting problems.

Folks, I saw this one coming years ago: In 2001 I warned my readers of the adverse effects from taking Bextra. This drug is just another cox-2 inhibitor disaster waiting to happen. Pain-killing drugs — meant to relieve symptoms but never the true condition — are rarely necessary.

Why take the risk of serious side effects from anti-inflammatories when you can create your OWN anti-inflammatory, merely by changing the ratio of omega-6 to omega-3 fats in your diet?

These two types of fatty acids are BOTH essential for human health. However, the typical American consumes far too many omega-6 fats and not enough omega-3 fats to be healthy.

While the ideal ratio of omega-6 to omega-3 fats should be 1:1, most people’s intake ratio averages from 20:1 to 50:1! This unbalanced intake could lead to several health problems, whereas proper consumption of omega-3 can help prevent disease or improve many chronic conditions such as:

* Breast cancer

* Diabetes

* Heart disease

* Ulcerative colitis

* Arthritis

* Childhood asthma

* Depression

* Hyperactivity

The easiest way to balance your ratio is to consume more omega-3 fats from good sources and to reduce your intake of omega-6 fats. The primary sources of omega-6 are corn, soy, and canola, safflower and sunflower oils; these foods are overabundant in the typical American diet, which explains our excess omega-6 levels. You want to avoid or limit these oils in order to be optimally healthy.

On the other hand, the best omega-3 fats are those found in fish. That’s because the omega-3 in fish is high in two fatty acids crucial to human health: DHA and EPA. Unfortunately, eating most fresh fish — whether from the ocean, lakes and streams or farm-raised — is no longer recommended.

This is because (if you are an avid reader of the newsletter then you already know) mercury levels in almost all fish around the world have now hit dangerously high levels, and the risks of mercury now heavily outweigh the benefits gained from fish-derived omega-3 fats.

Fortunately there are clean sources of fish oil you can access without having to worry about mercury levels and added toxins, Vital Choice Alaskan Wild Red Salmon comes from the relatively pristine waters of Alaska that have virtually no mercury pollution

Not only is this salmon mercury-free, but it is also loaded with omega-3 fatty acids EPA and DHA, is high in antioxidants to help you live longer and tastes absolutely delicious!

You can also achieve omega-3 benefits by taking fish oil and cod liver oil, as this is a clean, safe and pure alternative to fresh fish. I have researched brands and types of fish oil and cod liver oil extensively and can say with absolute confidence that I recommend Carlson’s brand fish oil and cod liver oil. Carlson’s fish oils are rigorously tested for potency and purity and is a healthy addition to most any diet.

Any teenager will tell you that acne can drive you crazy, but is it dismal enough to drive you to kill yourself? Since its market debut in 1982, enraged parents and lawyers have implicated Accutane in the hospitalizations and suicide deaths of over 200 teenagers in the US.

Accutane (isotretinoin) is one of Hoffman-LaRoche’s most popular and controversial pharmaceuticals. Doctors prescribe Accutane for patients with severe nodular acne that does not respond to systemic treatments with antibiotics.

Michigan Democrat Representative Bart Stupak lost his son, BJ, to suicide in May of 2000 while the teenager was using Accutane. Since then, Congressman Stupak has led a crusade for further research to establish Accutane’s risks of birth defects and psychiatric disorders like depression and suicide.

While the safety of isotretinoin is hotly contested, there are previous Accutane users such as 21 year-old Krista Savino who view the drug as a Godsend. The antithesis of Congressman Stupak, Savino vows to do whatever she can to keep Accutane on the market. Savino sometimes experiences acne so severe that she deems her condition the “social equivalent of suicide”. Accutane gives her clear skin and the confidence to leave her home without feeling overly self-conscious.

Hoffman-LaRoche, following FDA guidelines, lists depression as a possible Accutane side effect. Notwithstanding, the link between isotretinoin and the development of depression and/or suicide remains marred.

Like Senator Stupak, Dublin accountant Liam Grant, blames Roaccutane for the suicide death of his 20 year-old son, also named Liam. Grant alleges that his son exhibited signs of severe depression after taking Roaccutane in the months prior to his death.

According the British newspaper, The Sunday Times, Grant has spent almost

As a physician specializing in psychiatry, I know that many emotional conditions such as depression and anxiety disorders are true medical illnesses with a biologic (physical) origin. Psychiatry has become more and more “biological” in its diagnosis and treatment approaches during recent years, but a very significant stigma still exists against those who are seeing a therapist. This has become increasingly difficult to understand, but it is a social stigma that is so very important to eliminate.

Why does an embarrassment or stigma still exist associated with those who are seeking psychiatric treatment? Why do people wait so long before come for help - to the point of becoming nearly non-functional with their families, children and work environment?

First, many people have a picture in their mind of movies in which psychiatrists are ineffective listeners of problems of patients who are lying on psychoanalytic couches. It is important to remember that psychoanalysis preceded our modern treatment approaches which now have a much higher success rate. We currently have many safe and effective medications, which when used with or without psychotherapy, help many people fully recover.

Another reason for the stigma is in the use of the term “mental illness”. The field of psychiatry has undergone many changes in the past twenty years. Research into the functioning of the brain and nervous system has led to the concept of a “chemical imbalance” as the cause of illnesses such as Major Depression and Panic Attacks. In addition, Obsessive Compulsive Disorder, a condition portrayed so well by Jack Nicholson in the 1997 movie “As Good As It Gets,” is also caused by a chemical imbalance. Medications were used to help treat the “Obsessive Compulsive” character being played by Nicholson. Many psychiatric illnesses are not “mental” or “emotional,” but are now understood to be “neurochemical illnesses”.

Many people are told, “You can do this on your own, be strong,” as if a person can easily will themselves out of depression or anxiety. Can someone “Be Strong” and make their diabetes or bronchitis just go away? These types of suggestions only result in a delay in seeking treatment or feelings of failure in the individual who finally does seek help. The stigma of psychiatric treatment also leads many people to seek help at the health food store, or other types of self-diagnosis and self-medications.

Men in particular have to overcome an additional obstacle. It may seem “Un-Macho Like” to seek professional psychiatric help when one fails to understand or see their condition as an illness, and instead view it as a weakness in their character. Thus, injury to a man’s ego often contributes to their long delays in seeking treatment.

My hope is that the shame and secrecy associated with obtaining professional psychiatric help will gradually diminish and eventually cease to exist. If we understand how the social stigma was established in the first place - the media lack of medical knowledge, societies’ understanding or ignorance, etc., then we should realize there is no need to “stay in the closet.” Let’s wipe out the term “mental illness” and view many of these conditions as “neurochemical illness,” with the same non-prejudicial attitude as we do toward diseases such as diabetes or hypertension.

Depression is a disorder marked by sadness, low energy, impaired concentration, and feelings of dejection. Some people believe that depression is normal. Hectic daily activities and the conflict between family and career cause constant stress. Yet depression and anxiety as a response to stress are not normal. They can be signs of illness, which may worsen and result in physical symptoms or an inability to function.

Life was much simpler for the last two generations. Father worked; mother stayed home. This is no longer the model. Some now view families as an “endangered species.” There are more single mothers working than ever before. There is greater stress and competition for well-paying jobs. The result: long hours at work, away from the family. Children are raised with limited supervision. Thus we see more children with emotional problems derived from a lack of knowledge as to who they are and what their role is in today’s society. Similarly, adults suffer from the loss of nurturing that family time should provide.

Until recently, mental health was not discussed openly. However, there is a growing awareness that choosing therapy can be helpful, even necessary, to cope with today’s life. Psychiatric help is often sought for the entire family. Today, being healthy means not only having a sound body, but also a sound mind and spirit.

People exercise their bodies daily, yet they neglect to “exercise” their feelings and emotions. Young men are taught to hide and deny emotions. Women are reluctant to seek help in coping with their depression, anxiety, or distressed relationship. The same fitness fanatic who exercises daily, eats right and has two physicals a year will neglect the mind until a crisis is reached. Emotional problems don’t just happen, but are cumulative and they can be avoided at times with the same “daily fitness” and “annual physical” approach we use when caring for our bodies.

The Chinese say “the journey of a thousand miles begins with a single step.” Just like it’s better to maintain a healthy heart than recover from a heart attack, dealing with emotional issues is easier before the chaos of a crisis breaks. Think about “exercising your emotions” and give your mental health professional a call.

Debra S. Gorin, M.D. received her medical degree from the University of Miami School of Medicine. She is a diplomate of the American Board of Psychiatry and Neurology. She has been in private practice as a Psychiatrist for the past sixteen years in the Fort Lauderdale area. Dr. Gorin treats all types of stress-related, emotional and psychiatric problems of children, adolescents, and adults. She is also a trained hypnotherapist.

Irritable bowel syndrome sufferers often find that they have to deal with two sets of symptoms. The physical symptoms of diarrhea, constipation and pain form the main part of IBS, but sufferers may also develop emotional problems such as mild or moderate depression and anxiety because of the strain that IBS places on their lives.

There’s no doubt that IBS can have a huge impact on your mental and emotional health. One of the reasons why people assume that IBS is caused by stress is that IBS sufferers can appear so stressed and unhappy. But is this really surprising? If you had explosive diarrhea, never-ending constipation or stabbing stomach cramps you’d be a bit stressed too!

The nature of IBS symptoms can mean that they are very difficult to deal with, both practically, in terms of being afraid to go out because of fear of diarrhea, and emotionally, because of embarrassment and the sometimes unsympathetic reactions of others.

Sufferers find that their social lives quickly diminish to nothing, or that they can no longer eat the food at restaurants or dinner parties without ending up in pain. Work or school can become a chronic struggle as you drag yourself in on days when you feel ill, knowing that if you didn’t you’d get fired or kicked off your course.

You may also feel that you have to pretend to be healthy most of the time in spite of how you really feel, because people get tired of hearing about your condition or begin to say things like “Well why don’t you go to the doctor” or “My mum had that and ate lots of bran and now she’s fine. That’s what you should do.”

It can be very hard to bite your tongue and stop yourself answering back. “Oh, go to the DOCTOR, I see, that’s where I’ve going wrong all this time, I thought you had to go to the hardware store. I shall now be cured.”

What is important to remember is that anyone who is battling with IBS is going through a very difficult time, and deserves some genuine support, as does anyone with a chronic, long-term condition.

Hopefully, if you explain your condition to family and friends, support will be forthcoming, but if not you should ask yourself how much misunderstanding you are willing to put up with, and whether it is hazardous to your health.

This is what Heather Van Vorous says in The First Year - IBS: “You may even have friends or family dismiss your problem as ‘all in your head.’ It’s up to you to educate these people, and then dump them if they persist in their ignorance at the expense of your health.”

If they are truly your friends then they will want to learn about the condition and be ready to accept that their views are based on prejudice and assumption rather than fact.

But if they still believe that you’re exaggerating then ask them to explain exactly why they believe that IBS is psychosomatic or ‘all in your head’, what scientific studies they are basing their views on, and how they explain the success of new drugs such as the selective 5-HT3 antagonist Lotronex. That should keep them quiet.